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Test Name

Digoxin (Total)

Alternate Name/ Synonym

Cardiac glycoside

Alternate Gene Name


Test Code


Drug Class



Therapeutic Drug Monitoring - TDM


Abbott Architect ci4100

External Proficiency Testing


Turn Around Time

Daily (throughout the day)


Cardiac Glycoside

Clinical Significance

Digoxin is widely prescribed for the treatment of congestive heart failure and various disturbances of cardiac rhythm. Therapeutic use of digoxin improves the strength of myocardial contraction and results in the beneficial effects of increased cardiac output, decreased heart size, decreased venous pressure, and decreased blood volume. Digoxin therapy also results in stabilized and slowed ventricular pulse rate. In combination with other clinical and electrocardiographic data, serum digoxin levels provides the physician with useful information to aid in adjusting patient dosage at subtherapeutic and toxic drug levels.

Specimen Type

Serum, Plasma (Heparin or Citrate)

Minimum Specimen Requirements

300 uL

Optimal Collection Time

Trough: 0-30 minutes prior to dose
minimum 6-8 hrs after the dose


4°C (transport with a cool pack if possible)

Special Requirements

Note: If the patient is on Digibind therapy for the treatment of toxicity, the total digoxin result will be falsely elevated. Refer to the clinical significance for Digoxin (Free) for a complete description. In this case, both the Total and Free Digoxin levels should be requested.

Approval is not required

CPT Codes


Shipping and Contact Information

The Hospital for Sick Children
Rapid Response Laboratory
170 Elizabeth Street, Room 3642
Toronto, ON
M5G 2G3
Phone: 416-813-7200
Phone: 1-855-381-3212

Therapeutic Range

1.0–2.5 nmol/L

Critical Values

> 3.5 nmol/L

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