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Test Name

Estradiol (High Sensitivity), Blood

Test Code



Biochemistry - Biochemistry



External Proficiency Testing

IQMH; SKML (Foundation for Quality Assurance in Medical Laboratories)

Turn Around Time

15 days

Clinical Significance

Estradiol is the most potent natural estrogen in humans. It regulates  reproductive function in females, and, with progesterone, maintains pregnancy. Most estradiol is secreted by the ovaries (non-pregnant women), although the testes (in men) and adrenal cortex (in men and women) secrete small amounts. During pregnancy, the placenta produces most of the circulating estradiol. Monitoring estradiol levels is essential during in vitro fertilization, because the timing of recovery of oocytes depends on follicular development, which in turn depends on the estradiol level

Specimen Type

Serum:      Gold top SST

                   Red top

                   Lithium Heparin

Minimum Specimen Requirements


Collect 2mL of blood, spin, separate and ship frozen

Approval is not required

CPT Codes


Shipping and Contact Information

The Hospital for Sick Children
Rapid Response Laboratory
170 Elizabeth Street, Room 3642
Toronto, ON
M5G 2G3
Phone: 416-813-7200
Phone: 1-855-381-3212

Reference Range


Males (pmol/L)

Females (pmol/L)



30d - <1y*

1y - <10y

10y - 12y

12y - <15y

15y - <19y















Adults: ≥19y




Follicular phase 143-1377

Luteal phase 176-1615

Postmenopausal ≤37

* References ranges for estradiol are poorly defined in the first year of life.  Levels can be elevated at birth and subsequently fall to pre-pubertal levels within a year.

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