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Test Name

Detection of MLL-AF4 fusion gene; t(4;11) (q22;q23)

Gene Name

  • MLL-AF4 fusion gene


Haematopathology- Molecular Haematology


RT PCR (Real-time polymerase chain reaction) (end point)

External Proficiency Testing


Turn Around Time

2-3 working days


AML (Acute myeloid leukemia)

Clinical Significance

Chromosomal translocations involving the MLL gene located on 11q23 are implicated in various types of  acute lymphocytic leukemia and acute myeloid leukemia. MLL-AF4 fusion gene; t(4;11) (q22;q23) is one of the common translocations seen in infant leukemia.

Specimen Type

Peripheral Blood, Bone Marrow Aspirate

Minimum Specimen Requirements

2 mL


Room Temperature (on ice if shipping takes more than 48 hrs).

Special Requirements

Sample to be collected in EDTA or Sodium citrate (preservative). Please call Laboratory prior to shipping your samples.

Shipping and Contact Information

The Hospital for Sick Children
Rapid Response Laboratory
170 Elizabeth Street, Room 3642
Toronto, ON
M5G 2G3
Phone: 416-813-7200
Phone: 1-855-381-3212

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