Detection of MLL-AF4 fusion gene; t(4;11) (q22;q23)
- MLL-AF4 fusion gene
Haematopathology- Molecular Haematology
RT PCR (Real-time polymerase chain reaction) (end point)
External Proficiency Testing
Turn Around Time
2-3 working days
AML (Acute myeloid leukemia)
Chromosomal translocations involving the MLL gene located on 11q23 are implicated in various types of acute lymphocytic leukemia and acute myeloid leukemia. MLL-AF4 fusion gene; t(4;11) (q22;q23) is one of the common translocations seen in infant leukemia.
Peripheral Blood, Bone Marrow Aspirate
Minimum Specimen Requirements
Room Temperature (on ice if shipping takes more than 48 hrs).
Sample to be collected in EDTA or Sodium citrate (preservative). Please call Laboratory prior to shipping your samples.
Shipping and Contact Information
The Hospital for Sick Children
Rapid Response Laboratory
170 Elizabeth Street, Room 3642
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Toll Free: 1-855-381-3212